Power and Sample Size Calculations for Primary Open Angle Glaucoma / Ocular Hypertension Clinical Trials Accounting for Correlation of Measures among the Time Points across Visits

Dale Usner, Ph.D., Richard Abelson, Ph.D.
ARVO Annual Meeting, May 2014

Historically, the correlation among time points within a subject/eye has not been overtly accounted for when determining power and sample size for clinical trials in primary open angle glaucoma/ocular hypertension. This poster details:

  • The importance of accounting for the correlation of measures among time points 
  • How the number of time points and correlation among time points affect power and sample size
  • How these variables affect Type I Error (the probability of rejecting the null hypothesis and concluding non-inferiority, when the null hypothesis is true; also known as alpha)

To access this poster, please complete the short form to the right.