Evaluation and Selection of Statistical Analyses for Diary Data in Dry Eye Studies

Hui-Chun T. Hsu, Kathryn S. Kennedy, Dale Usner, Dale J. Kennedy, Richard Abelson
ARVO Annual Meeting, May 2012

Patient symptom diaries are a commonly used method to collect efficacy data in clinical trials, such as those for dry eye treatments. This poster details:

  • Various statistical methodologies commonly used to analyze diary data
  • Evaluation of each methodology in terms of power and risk of Type I Error inflation
  • Recommended mixed model approach based on simulated analysis

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