Evaluation and Selection of Statistical Analyses for Diary Data in Dry Eye Studies
Hui-Chun T. Hsu, Kathryn S. Kennedy, Dale Usner, Dale J. Kennedy, Richard Abelson
ARVO Annual Meeting, May 2012
Patient symptom diaries are a commonly used method to collect efficacy data in clinical trials, such as those for dry eye treatments. This poster details:
- Various statistical methodologies commonly used to analyze diary data
- Evaluation of each methodology in terms of power and risk of Type I Error inflation
- Recommended mixed model approach based on simulated analysis
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